| Platinum Splattin' 'Em! | Platinum | Earn all trophies |
| You da Man, Chris | Silver | Finish the game as Chris |
| Alpha Team's Finest | Silver | Finish the game as Jill |
| We're in This Together | Silver | Finish the game with both Jill and Chris |
| Don't Stop Running | Silver | Finish the game in three hours |
| Racing and Pacing | Silver | Finish the game in five hours |
| CQC FTW | Silver | Finish the game using only your knife |
| Ink is for Squids | Silver | Finish the game without saving |
| Starsenal | Silver | Obtain all weapons |
| Ghost of a Chance | Gold | Finish the game in Invisible Enemy mode |
| First Kills Are Special | Bronze | Defeat a zombie |
| Get Used To It | Bronze | Die for the first time |
| Not Taking Any Chances | Bronze | Burn up a zombie |
| Seeing Red | Bronze | Defeat a Crimson Head |
| Who's the Hunter Now? | Bronze | Defeat a Hunter |
| Every Nook and Cranny | Bronze | Visit all places on all maps |
| Passion for Fashion | Bronze | Obtain all costumes |
| Like Taking Candy from a Baby | Bronze | Finish on Very Easy or higher |
| Not in the Mood to Die | Bronze | Finish on Easy or higher |
| Take that, Zombies! | Bronze | Finish on Normal or higher |
| Oh, the Horror | Silver | Finish the game on Hard |
| The Survival Horror | Silver | Finish the game in Real Survival mode |
